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- bs-0091P
- 2025年10月16日
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500ug
| 产品编号 | bs-0091P |
| 英文名称 | CA125 Antibody Blocking Peptide |
| 中文名称 | 卵巢癌抗原封闭多肽 |
| 英文别名 | CA 125; CA125; CA-125; CA125 ovarian cancer antigen; Cancer antigen 125; FLJ14303; MUC16_HUMAN; MUC 16; MUC16; Mucin 16; MUC-16; Mucin 16 cell surface associated; Mucin16; Ovarian cancer related tumor marker CA125; Ovarian carcinoma antigen CA125; Ovarian cancer-related tumor marker CA125. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix > MUC Cancer > Tumor biomarkers Cancer > Tumor biomarkers > Tumor antigens Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > MUC |
| 亚基 | Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain. |
| 组织特异性 | Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. |
| 翻译后修饰 | Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts. |
| 相似性 | Contains 2 ANK repeats.
Contains 56 SEA domains. |
| 功能 | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | MUC16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000 kDa with smaller “subunits” being described by some investigators. |
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文献和实验[IF={{ 8.008 }}] {Li Fu. et al. A General Route for Chemiluminescence of n-Type Au Nanocrystals. ANAL CHEM. 2022;94(24):8811–8817} {Other} {}
[IF={{ 8.008 }}] {Xuwen Gao. et al. Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay. ANAL CHEM. 2022;XXXX(XXX):XXX-XXX} {Other} {}
[IF={{ 6.785 }}] {Li Fu. et al. Surface-Defect-Induced and Synergetic-Effect-Enhanced NIR-II Electrochemiluminescence of Au–Ag Bimetallic Nanoclusters and Its Spectral Sensing. Anal Chem. 2021;XXXX(XXX):XXX-XXX} {Other} {}
[IF={{ 5.999 }}] {Zhi Luo. et al. An electrochemiluminescence immunosensor based on ABEI-GO-AgNPs as a double-amplified luminophore for the ultra-sensitive detection of prostate-specific antigen. COLLOID SURFACE B. 2022 Oct;218:112718} {Other} {}
[IF={{ 5.479 }}] {Zheng X et al. Electrochemiluminescent immunoassay for neuron specific enolase by using amino-modified reduced graphene oxide loaded with N-doped carbon quantum dots. Mikrochim Acta. 2019 Nov 20;186(12):817.} {Other} {}
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