BIN1 Antibody Blocking Peptide(bs-1485P)-500ug

BIN1 Antibody Blocking Peptide

(bs-1485P)-500ug
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  • bs-1485P
  • 2025年10月16日
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    北京博奥森生物技术有限公司
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      500ug

    产品编号bs-1485P
    英文名称BIN1 Antibody Blocking Peptide
    中文名称桥连整合因子蛋白封闭多肽
    英文别名Amphiphysin like protein; AMPH 2; AMPH2; Amphiphysin 2; Amphiphysin II; Amphiphysin like protein; amphiphysin-like; AMPHL; Box Dependant MYC Interacting Protein 1; Bridging Integrator 1; DKFZp547F068; MGC10367; MGC105358; Myc box dependent interacting protein 1; SH3P9; BIN1_HUMAN.
    纯化方法HPLC
    研究领域

    Cancer > Cell cycle > Cell cycle inhibitors

    Cancer > Oncoproteins/suppressors > Tumor suppressors

    Cell Biology > Cell Cycle > Cell Cycle Inhibitors

    Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors

    Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors

    Microbiology > Interspecies Interaction > Host Virus Interaction

    亚基Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Isoform IIA interacts with CLTC. Isoform IIB does not interact with CLTC. Isoform IIC1 does not interact with CLTC. Isoform IIC2 does not interact with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts (SH3 domain) with HCV NS5A.
    亚细胞定位Isoform BIN1: Nucleus.
    Isoform IIA: Cytoplasm.
    组织特异性Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
    翻译后修饰Phosphorylated by protein kinase C.
    相似性Contains 1 BAR domain.
    Contains 1 SH3 domain.
    功能May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The identification and analysis of tumor suppressors is of major importance for improved diagnosis and treatment of tumors. Bin1 (Box-dependent myc interacting protein 1, also known as SH3P9, amphiphysin II and amphl/amphiphysin-like) is a novel protein that has features of a tumor suppressor. Bin1 interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Bin1 also interacts with HCV NS5A through its SH3 domain.

     

     

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