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- Bioss
- bs-12337P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-12337P |
| 英文名称 | MAEA Antibody Blocking Peptide |
| 中文名称 | 细胞增殖诱导蛋白5/肺癌相关蛋白10封闭多肽 |
| 英文别名 | 1110030D19Rik; Cell proliferation inducing gene 5 protein; Cell proliferation-inducing gene 5 protein; EMP; Erythroblast macrophage protein; HLC 10; HLC-10; HLC10; Human lung cancer oncogene 10 protein; Lung cancer related protein 10; lung cancer-related protein 10; Macrophage erythroblast attacher; MAEA; MAEA_HUMAN; MGC93683; PIG5; proliferation-inducing gene 5. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Macrophage / Inflamm. Stem Cells > Hematopoietic Progenitors > Myeloid > Erythrocytic Lineage |
| 亚基 | Forms a complex with F-actin. |
| 亚细胞定位 | Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Contains 1 CTLH domain. Contains 1 LisH domain. |
| 功能 | Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Emp is a 396 amino acid ubiquitously expressed adhesion protein. Expressed as 5 alternatively spliced isoforms, Emp contains one CTLH domain and one LisH domain. Emp can form a complex with F-actin, which is involved regulating actin distribution in erythroblasts and macrophages. Considered to assist with cell division and nuclear architecture, Emp is localized with condensed chromatin at prophase, nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis. Although the exact function of Emp is unknown, Emp is suggested to be involvement in erythroblast-macrophage cell attachment, terminal maturation and enucleation of erythroid cells, and inhibiting apoptosis of erythroblasts. |
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MAEA Antibody Blocking Peptide(bs-12337P)-500ug
￥880
