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- bs-12317P
- 2025年10月16日
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500ug
| 产品编号 | bs-12317P |
| 英文名称 | SCUBE3 Antibody Blocking Peptide |
| 中文名称 | 新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3封闭多肽 |
| 英文别名 | CEGF3; CUB and EGF containing protein 3; CUB and EGF-like domain-containing protein 3; CUB domain and EGF like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; OTTHUMP00000016250; SCUB3_HUMAN; SCUBE 3; SCUBE3; Signal peptide; Signal peptide CUB and EGF like domain containing protein 3; Signal peptide CUB domain EGF like 3. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Hypertrophy Developmental Biology > Organogenesis > Skeletal development > Bone Signal Transduction > Growth Factors/Hormones > TGF |
| 亚基 | Forms homooligomers and heterooligomers with SCUBE1.Interacts with TGFBR2 through the CUB domain; this interaction doesnot affect TGFB1-binding to TGFBR2. |
| 亚细胞定位 | Secreted. Cell surface. |
| 组织特异性 | Highly expressed in osteoblasts. Expression is low or absent in non-bone tissues. |
| 翻译后修饰 | N-glycosylated. May undergo proteolytic cleavage in the C-terminal region. |
| 相似性 | Contains 1 CUB domain. Contains 9 EGF-like domains. |
| 功能 | Binds to TGFBR2 and activates TGFB signaling. In lungcancer cells, could serve as an endogenous autocrine and paracrineligand of TGFBR2, which could regulate TGFBR2 signaling and hencemodulate epithelial-mesenchymal transition and cancer progression. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SCUBE3 is a novel secreted 993 amino acid cell-surface osteoblast protein that plays an important role in bone cell biology. While highly expressed in osteoblasts, SCUBE3 expression is unobservable or very low in non-bone tissues. SCUBE3 forms homo-oligomers and hetero-oligomers with SCUBE1, and may undergo C-terminal proteolytic cleavage or become N-glycosylated following translation. Two SCUBE3 isoforms exist as a result of alternative splicing events. SCUBE3 contains one CUB domain and nine EGF-like domains, and is encoded by a gene which maps to human chromosome 6p21.31, a region associated with a rare form of metabolic bone disease known as Paget's disease. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. |
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SCUBE3 Antibody Blocking Peptide(bs-12317P)-500ug
￥880
