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- bs-16413P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-16413P |
| 英文名称 | ZRANB2 Antibody Blocking Peptide |
| 中文名称 | 锌指蛋白ZNF265封闭多肽 |
| 英文别名 | ZRANB 2; DKFZp686J1831; DKFZp686N09117; FLJ41119; OTTHUMP00000011240; OTTHUMP00000011241; ZRAB2_HUMAN; Zinc finger protein 265; Zinc finger RAN binding domain containing 2; Zinc finger Ran binding domain containing protein 2; Zinc finger splicing; ZIS; ZIS1; ZIS2; ZNF265. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1. |
| 亚细胞定位 | Nuclear |
| 翻译后修饰 | Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the ZRANB2 family. Contains 2 RanBP2-type zinc fingers. |
| 功能 | ZRANB2 is a splice factor required for alternative splicing of SFRS10/TRA2B transcripts. It may interfere with constitutive 5'-splice site selection. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2∫ (transformer-2 beta) transcripts and is thought to interfere with constitutive 5’-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR. |
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ZRANB2 Antibody Blocking Peptide(bs-16413P)-500ug
￥880
