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- Bioss
- bs-16407P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-16407P |
| 英文名称 | ZRANB3 Antibody Blocking Peptide |
| 中文名称 | ZRANB3蛋白封闭多肽 |
| 英文别名 | 4933425L19Rik; MGC105033; MGC75012; OTTHUMP00000197449; Zinc finger Ran-binding domain-containing protein 3; Zinc finger, RAN- binding domain containing 3; ZRAB3_HUMAN; Zranb3. |
| 纯化方法 | HPLC |
| 亚基 | Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin). |
| 亚细胞定位 | Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA. |
| 相似性 | Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 RanBP2-type zinc finger. |
| 功能 | DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Zinc finger Ran-binding domain-containing protein 3 (ZRANB3) is a 1079 amino acid gene product that belongs to the SNF2/RAD54 helicase family. Other family members are known to be involved in DNA repair and mitotic recombination. This family of proteins often plays an active role in recombination processes in cooperation with other members of the RAD52 epistasis group. The ZRANB3 product contains one helicase ATP-binding domain, one helicase C-terminal domain and one RanBP2-type zinc finger. RanBP2-type zinc fingers mediate the helicase binding to RNA. Similar to other Ran-binding zinc finger proteins, ZRANB3 likely acts as a splice factor for alternative splicing events of pre-mRNA transcripts. ZRANB proteins may also interfere with constitutive 5'-splice site selection. |
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ZRANB3 Antibody Blocking Peptide(bs-16407P)-500ug
￥880
