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- 2025年10月16日
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500ug
| 产品编号 | bs-1473P |
| 英文名称 | AKAP8 Antibody Blocking Peptide |
| 中文名称 | 蛋白激酶A锚定蛋白95封闭多肽 |
| 英文别名 | AKAP8; AKAP-8; AKAP-95; A-kinase Anchoring Protein 95; CCK 1; CCK1; CCL 28; Chemokine (C-C motif) ligand 28; MEC; Mucosae associated epithelial chemokine; SCYA28; Small inducible cytokine A28; AKP8L_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Kinases/Phosphatases |
| 亚基 | Interacts with PRPF40A. Binds to the C-terminal of RNA helicase A and to TMPO-beta. Interacts with RNF43. |
| 亚细胞定位 | Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix. Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix. |
| 组织特异性 | Expressed in the brain cortex (at protein level). |
| 翻译后修饰 | Phosphorylated on serine or threonine residues possibly by PKA. |
| 相似性 | Belongs to the AKAP95 family.
Contains 2 C2H2 AKAP95-type zinc fingers. |
| 功能 | Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011] |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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