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- bs-13597P
- 2025年10月16日
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500ug
| 产品编号 | bs-13597P |
| 英文名称 | HESX1 Antibody Blocking Peptide |
| 中文名称 | 同源结构域转录因子HESX1封闭多肽 |
| 英文别名 | HESX1_HUMAN; Homeobox expressed in ES cells 1; Homeobox protein ANF; hAnf. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Embryogenesis > Embryonic stem cells > Surface molecules Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Stem Cells > Embryonic Stem Cells > Intracellular |
| 亚基 | Can form heterodimers with PROP1 in binding to DNA (By similarity). Interacts with TLE1. |
| 亚细胞定位 | Nuclear |
| 相似性 | Belongs to the ANF homeobox family. Contains 1 homeobox DNA-binding domain. |
| 功能 | Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The homeobox protein, HESX1, which is also known as Rathke’s pouch homeobox, HANF, homeodomain transcription factor, and anterior-restricted homeobox protein is a transcription factor that belongs to the homeodomain family of DNA binding proteins. HESX1 is initially expressed in embryonic stem cells and the primitive forebrain, and is essential for normal development of the eyes and other anterior CNS structures, such as the hypothalamus, the pituitary gland and the olfactory bulbs. The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early embryogenesis. Mutations in the Hesx1 gene are associated with disorders that are comparable with septo-optic dysplasia (SOD). These disorders are characterized by hypoplasia of the optic nerve, various types of forebrain defects and pituitary hormone deficiencies, including hypothyroidism. Hesx1 also acts as a transcriptional repressor of reporter gene constructs in tissue culture assays. |
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HESX1 Antibody Blocking Peptide(bs-13597P)-500ug
￥880
