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- Bioss
- bs-12303P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12303P |
| 英文名称 | HEMGN Antibody Blocking Peptide |
| 中文名称 | 红细胞分化相关基因蛋白封闭多肽 |
| 英文别名 | EDAG; EDAG-1; Erythroid differentiation-associated gene protein; HEMGN; HEMGN_HUMAN; Hemogen; Hemopoietic gene protein; Negative differentiation regulator protein. |
| 纯化方法 | HPLC |
| 研究领域 | Stem Cells > Hematopoietic Progenitors > Intracellular Molecules |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in fetal liver, kidney and brain. Expressed in hematopoietic precursor cells (at protein level). Detected in CD34+ and K562 leukemia cell line (at protein level). Expressed in bone marrow, testis, thymus. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. |
| 功能 | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hemogen is a 484 amino acid protein encoded by the human gene HEMGN. Hemogen is a nuclear protein that is expressed in hematopoietic precursor cells and can be detected in CD34+ and K-562 leukemia cell line. It is also expressed in bone marrow, testis, thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. Hemogen is down-regulated during megakaryocytic differentiation of K-562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). It can be up-regulated in normal PBMCs by mitogens. |
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HEMGN Antibody Blocking Peptide(bs-12303P)-500ug
￥880
