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- bs-12302P
- 2025年10月16日
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500ug
| 产品编号 | bs-12302P |
| 英文名称 | EDR1/PHC1 Antibody Blocking Peptide |
| 中文名称 | 早期发育调控蛋白1/EDR1封闭多肽 |
| 英文别名 | Early development regulatory protein 1; EDR1 PH1; hPH1; mPH1; PH1; EDR1; Polyhomeotic-like protein 1; Rae28; PHC1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing > PRC1 Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing > PRC2 Stem Cells > Hematopoietic Progenitors > Intracellular Molecules |
| 亚细胞定位 | Nuclear. |
| 相似性 | Contains 1 FCS-type zinc finger. Contains 1 SAM (sterile alpha motif) domain. |
| 功能 | PHC1 is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The Polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators, such as Hox genes, and thus are essential for proper development. PHC1 is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. PHC1, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | PHC1 is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. |
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EDR1/PHC1 Antibody Blocking Peptide(bs-12302P)-500ug
￥880
