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- bs-23115P
- 2025年10月16日
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500ug
| 产品编号 | bs-23115P |
| 英文名称 | connexin-30 Antibody Blocking Peptide |
| 中文名称 | 间隙连接蛋白30/GJB6封闭多肽 |
| 英文别名 | Connexin 30; Connexin-30; Cx30; CXB6_HUMAN; DFNA3; ectodermal dysplasia 2, hidrotic (Clouston syndrome); ED2; EDH; Gap junction beta 6 protein; Gap junction beta-6 protein; gap junction protein, beta 6 (connexin 30); gap junction protein, beta 6; GJB6; HED; NSRD1. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Sensory System > Auditory system Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Gap Junctions |
| 亚基 | A connexon is composed of a hexamer of connexins. Interacts with CNST |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. |
| 相似性 | Belongs to the connexin family. Beta-type (group I) subfamily. |
| 功能 | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neiGHBoring cell. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The connexin family of proteins form hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences between connexins arise from specific amino-acid substitutions in the most highly conserved domains: the transmembrane and extracellular regions. Connexin 30, also known as GJB6 (Gap junction beta 6), ED2, EDH, HED or DFNA3, is a 261 amino acid multi-pass membrane protein that localizes to the cell junction and belongs to the connexin family. Functioning as a hexamer with other connexin proteins, connexin 30 facilitates the diffusion of low molecular weight materials from one cell to another. Defects in the gene encoding connexin 30 are the cause of ectodermal dysplasia type 2 (ED2) and non-syndromatic sensorineural deafness autosomal dominant type 3 (DFNA3), the former of which is characterized by abnormal development of ectodermal structures (such as skin and nails). |
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文献和实验Blocking of unwanted non-specific staining
is not. Blocking of endogenous peroxidase is done by preincubating the slides in 3 H2O2 1 Sodium Azide PBS 30 minutes several washes This mixture is more effective than 1.5 H2O2 in absolute methanol Ref. Methanol incubation is also a fixation step
or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Polyclonal Antibody Production
or cloned and expressed as a fusion protein with a larger protein. If it is a peptide or small molecule, a carrier-hapten conjugate must be made. Purify your antigen well to obtain antibodies with good specificity. Obtain at least two 6 week old New
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