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- Bioss
- bs-11040P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11040P |
| 英文名称 | BEST1 Antibody Blocking Peptide |
| 中文名称 | 卵黄状黄斑病蛋白封闭多肽 |
| 英文别名 | BEST 1; BEST1; BEST-1; BEST; Best macular dystrophy; BEST1; BEST1_HUMAN; Bestrophin 1; Bestrophin-1; Bestrophin1; BMD; mBest1; TU15B; Vitelliform macular dystrophy 2; Vitelliform macular dystrophy; Vitelliform macular dystrophy protein 2; VMD 2; VMD2. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > ECM Proteins Neuroscience > Sensory System > Visual system |
| 亚基 | Tetramer or pentamers. May interact with PPP2CB and PPP2R1B. |
| 亚细胞定位 | Cell membrane. Basolateral cell membrane. |
| 组织特异性 | Predominantly expressed in the basolateral membrane of the retinal pigment epithelium. |
| 翻译后修饰 | Phosphorylated by PP2A. |
| 相似性 | Belongs to the bestrophin family. |
| 功能 | Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Best vitelliform macular dystrophy, known as Best disease, is an early-onset autosomal dominant condition in which accumulation of lipofuscin-like material within and beneath the RPE leads to progressive loss of central vision. Best disease is frequently a reflection of mutations in the Bestrophin gene, which encodes a protein containing four putative transmembrane domains and localizes to the basolateral plasma membrane of RPE cells. Human Bestrophin forms oligomeric chloride channels that are sensitive to intracellular calcium. Missense mutations at the Bestrophin locus reduces or abolishes Bestrophin protein mediated membrane current. Bestrophin Bestrophin 2,Bestrophin 3, and Bestrophin 4 are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. |
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BEST1 Antibody Blocking Peptide(bs-11040P)-500ug
￥880
