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- bs-16383P
- 2025年10月16日
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500ug
| 产品编号 | bs-16383P |
| 英文名称 | XRN1 Antibody Blocking Peptide |
| 中文名称 | XRN1蛋白封闭多肽 |
| 英文别名 | XRN1_HUMAN; Dhm2; mXRN1; SEP1; Strand-exchange protein 1 homolog; 5'-3' exoribonuclease 1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Epigenetics and Nuclear Signaling > RNAi > Argonaute and Piwi |
| 亚基 | Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages. |
| 亚细胞定位 | Nuclear. |
| 组织特异性 | Expressed in many tissues. Most abundant in adult thymus and fetal liver. |
| 翻译后修饰 | Phosphorylated in a mitose-specific manner. |
| 相似性 | Belongs to the LEM family. Contains 1 LEM domain. Contains 1 LEM-like domain. |
| 功能 | Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent- and salt-resistant nucleoskeletal structure. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
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XRN1 Antibody Blocking Peptide(bs-16383P)-500ug
￥880
