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- 2025年10月16日
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| 产品编号 | bs-17432P |
| 英文名称 | Histone H2B (acetyl K12) Antibody Blocking Peptide |
| 中文名称 | 乙酰化组蛋白H2B K12封闭多肽 |
| 英文别名 | H2B 1A; H2B; H2B histone family; H2B2f; H2B2F_HUMAN; H2Ba; H2Bf; HIST2H2BF; histone H2B; histone H2B type 1; Histone H2B type 2-F; MGC131639. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies |
| 亚细胞定位 | Nucleus. Chromosome. |
| 翻译后修饰 | Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. |
| 相似性 | Belongs to the histone H2B family. |
| 功能 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Jan 2013] |
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文献和实验IHC IC2575Acetyl-Histone H2B (Lys12) AntibodyRabbitW IHC IC2571Acetyl-Histone H2B (Lys20) AntibodyRabbitW IP IHC IC2574Acetyl-Histone H2B (Lys5) AntibodyRabbitW IP IHC IC9675Acetyl-Histone H3 (Lys18) AntibodyRabbitW IHC IC9674Acetyl-Histone H3 (Lys23
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Identification of Protein Interactions by Far Western Analysis
1, Coomassie blue–stained gel showing locations of histone bands. Lane 2, far western of a parallel lane using radiolabeled in vitro–translated probe. Lane 3, far western using unlabeled probe detected with probe‐specific antibody. Lane 4, western blot using
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