- ￥880
- Bioss
- bs-12277P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12277P |
| 英文名称 | SOX7 Antibody Blocking Peptide |
| 中文名称 | 转录因子SOX7封闭多肽 |
| 英文别名 | MGC10895; SOX 7; SOX 7 transcription factor; sox7; SOX7 transcription factor; SOX7_HUMAN; SRY (sex determining region Y) box 7; SRY box 7; SRY sex determining region Y box 7; Transcription factor SOX 7; Transcription factor Sox-7; Transcription factor SOX7. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Lineage specification > Endoderm Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Stem Cells > Lineage Markers > Endoderm |
| 亚基 | Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. |
| 相似性 | Contains 1 HMG box DNA-binding domain. Contains 1 Sox C-terminal domain. |
| 功能 | Transcriptional repressor. Binds to the DNA sequence 5'-AACAAT-3'. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. |
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SOX7 Antibody Blocking Peptide(bs-12277P)-500ug
￥880
