- ￥880
- Bioss
- bs-12272P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12272P |
| 英文名称 | NANOS1 Antibody Blocking Peptide |
| 中文名称 | 生殖细胞增殖相关蛋白NANOS1封闭多肽 |
| 英文别名 | EC Rep1a; EC_Rep1a; NANO1_HUMAN; NANOS 1; Nanos homolog 1 (Drosophila); Nanos homolog 1; NANOS1; Nos 1; NOS-1; Nos1; OTTHUMP00000046853; Rep 1a; Rep1a; Nanos Homologue 1. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Reproduction > Germ cell markers Epigenetics and Nuclear Signaling > DNA / RNA > Translation > Regulation Stem Cells > Germline Stem Cells > Embryonic Germ Cells |
| 亚基 | Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. |
| 相似性 | Belongs to the nanos family. Contains 1 nanos-type zinc finger. |
| 功能 | May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nanos1is a 292 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one nanos-type zinc finger. Expressed at high levels in spermatogonia and present at lower levels in fetal ovaries, Nanos1 forms a complex with Pumilio 2 and functions to regulate the translation of select mRNAs, specifically via association with the 3’-UTR of its mRNA targets. Additionally, Nanos1 is required for the establishment and maintenance of germline stem cells, as it prevents their premature entry into oogenesis. The gene encoding Nanos1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. |
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NANOS1 Antibody Blocking Peptide(bs-12272P)-500ug
￥880
