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- Bioss
- bs-0538P
- 2025年10月16日
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500ug
| 产品编号 | bs-0538P |
| 英文名称 | Cdkn1c Antibody Blocking Peptide |
| 中文名称 | 周期蛋白依赖激酶抑制因子1C封闭多肽 |
| 英文别名 | Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip2; p57 Kip 2; p57Kip2; WBS; IMAGE; CDN1C_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors > Cip/kip Cell Biology > Cell Cycle > Cell Cycle Inhibitors > Cip / Kip Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors > Cip/Kip |
| 亚基 | Interacts with PCNA. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver. |
| 相似性 | Belongs to the CDI family. |
| 功能 | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. |
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Cdkn1c Antibody Blocking Peptide(bs-0538P)-500ug
￥880
