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- bs-13544P
- 2025年10月16日
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500ug
| 产品编号 | bs-13544P |
| 英文名称 | GUCY1A1 Antibody Blocking Peptide |
| 中文名称 | 鸟苷酸环化酶α1/GCS-α-1封闭多肽 |
| 英文别名 | GC S alpha 1; GC SA3; GCS alpha 1; GCS alpha 3; GCS-alpha-1; GCS-alpha-3; GCYA3_HUMAN; Guanylate cyclase 1 soluble alpha 3; Guanylate cyclase soluble subunit alpha 1; Guanylate cyclase soluble subunit alpha 3; Guanylate cyclase soluble subunit alpha-3; Guc1a1; GUC1A3; GUCA3; GUCSA3; Gucy1a1; Gucy1a3; Soluble guanylate cyclase large subunit; α1 Soluble Guanylyl Cyclase; sGCα1. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Vasculature > Vasodilation Cardiovascular > Vasculature > Vasodilation > Nitric oxide associated Signal Transduction > Second Messenger > Nucleotide Messenger > cGMP |
| 亚基 | Heterodimer of an alpha and a beta chain. |
| 亚细胞定位 | Cytoplasm. |
| 相似性 | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. |
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GUCY1A1 Antibody Blocking Peptide(bs-13544P)-500ug
￥880
