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- Bioss
- bs-16350P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-16350P |
| 英文名称 | GTF2H2 Antibody Blocking Peptide |
| 中文名称 | 通用转录因子2H亚基2/TFIIH p44封闭多肽 |
| 英文别名 | Basic transcription factor 2 44 kDa subunit; BTF2; BTF2 p44; BTF2-p44; BTF2P44; General transcription factor IIH; General transcription factor IIH polypeptide 2; General transcription factor IIH subunit 2; General transcription factor IIH, polypeptide 2, 44kDa; Gtf2h2; MGC102806; p44; T BTF2P44; T-BTF2P44; TF2H2_HUMAN; TFIIH; TFIIH basal transcription factor complex p44 subunit. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Nucl. Excision Repair Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription > TFIIH Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3. Interacts with varicella-zoster virus IE63 protein. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Widely expressed, with higher expression in skeletal muscle. |
| 相似性 | Belongs to the GTF2H2 family. Contains 1 VWFA domain. |
| 功能 | Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neiGHBoring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008] |
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GTF2H2 Antibody Blocking Peptide(bs-16350P)-500ug
￥880
