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- bs-11953P
- 2025年10月16日
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500ug
| 产品编号 | bs-11953P |
| 英文名称 | SLC25A12/ARALAR Antibody Blocking Peptide |
| 中文名称 | 钙结合线粒体载体蛋白封闭多肽 |
| 英文别名 | AGC1; Araceli hiperlarga; ARALAR; ARALAR1; Calcium binding mitochondrial carrier superfamily member; Calcium-binding mitochondrial carrier protein Aralar1; CMC1_HUMAN; Mitochondrial aspartate glutamate carrier 1; SLC25A12; Solute carrier family 25 member 12; solute carrier family 25, member 12. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Pathways and Processes > Metabolic signaling pathways > Amino acid metabolism Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Neuroscience > Neurology process > Neurogenesis Neuroscience > Neurotransmitter > Amino Acids > Aspartate Neuroscience > Neurotransmitter > Amino Acids > Glutamate Neuroscience > Neurotransmitter > Transporters > Glutamate Neuroscience > Neurotransmitter > Transporters > Other Transporters Signal Transduction > Metabolism > Amino Acids Signal Transduction > Metabolism > Mitochondrial Signal Transduction > Signaling Pathway > Calcium Signaling Tags & Cell Markers > Subcellular Markers > Organelles > Mitochondria |
| 亚细胞定位 | Mitochondrion inner membrane. |
| 组织特异性 | High levels in heart and skeletal muscle, low in brain and very low in kidney. |
| 相似性 | Belongs to the mitochondrial carrier family. Contains 4 EF-hand domains. Contains 3 Solcar repeats. |
| 功能 | Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia. |
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