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- Bioss
- bs-1282P
- 2025年10月16日
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500ug
| 产品编号 | bs-1282P |
| 英文名称 | PPP1R12B Antibody Blocking Peptide |
| 中文名称 | p53凋亡刺激蛋白1封闭多肽 |
| 英文别名 | p53BP2 like; p85; PPP1R13B; apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Oncoproteins > Signal transducers Stem Cells > Endothelial Progenitors > Endothelial Markers |
| 亚基 | Interacts with TP53. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear. |
| 组织特异性 | Reduced expression in breast carcinomas expressing a wild-type TP53 protein. |
| 相似性 | Belongs to the ASPP family.
Contains 2 ANK repeats. Contains 1 SH3 domain. |
| 功能 | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFKap B-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFKap B (RelA),3 interacts with NFKap B in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFKap b and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. Alternate Names: apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51. |
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PPP1R12B Antibody Blocking Peptide(bs-1282P)-500ug
￥880
