- ￥880
- Bioss
- bs-11913P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11913P |
| 英文名称 | NPDC1 Antibody Blocking Peptide |
| 中文名称 | 神经细胞增殖和分化调控蛋白1封闭多肽 |
| 英文别名 | AI314472; CAB1; Neural proliferation differentiation and control protein 1; NPDC-1; NPDC1; NPDC1_HUMAN. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Membrane; Single-pass membrane protein (Potential). |
| 组织特异性 | Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe. |
| 相似性 | Belongs to the NPDC1/cab-1 family. |
| 功能 | Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human. |
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NPDC1 Antibody Blocking Peptide(bs-11913P)-500ug
￥880
