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- Bioss
- bs-13191P
- 2025年10月16日
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500ug
| 产品编号 | bs-13191P |
| 英文名称 | FNDC3A Antibody Blocking Peptide |
| 中文名称 | Ⅲ型纤维连接蛋白域蛋白3A封闭多肽 |
| 英文别名 | Fibronectin type III domain containing protein 3a; FNDC3; HUGO; KIAA0970; FND3A_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Tags & Cell Markers > Cell Type Markers > Other Cell Types |
| 亚细胞定位 | Golgi apparatus membrane; Single-pass membrane protein (Potential). |
| 组织特异性 | Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney. |
| 相似性 | Belongs to the FNDC3 family. Contains 9 fibronectin type-III domains. |
| 功能 | FNDC3A is a member of a three-gene family in mice. It is expressed in several tissues including testis, and encodes a novel protein composed of a proline-rich amino-terminus, nine fibronectin type-III domains, and a hydrophobic carboxy-terminus. The proline-rich region of each family member contains conserved amino acids that include a PPGY consensus binding site for type I WW domain containing proteins. The hydrophobic carboxy-terminus is similar to that found in 'tail-anchored' proteins, integral membrane proteins that are localized to the cytosolic face of the endoplasmic reticulum. Immunohistochemical staining has shown that FNDC3A localizes to the acrosome of spermatids, as well as to Leydig cells in the mouse testis. FNDC3A may be involved in mediating spermatid-Sertoli adhesion during mouse spermatogenesis and mutation of FNDC3A is the cause of male sterility in sys mice. FNDC3A has also been found to be overexpressed in human odontoblasts. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FNDC3A is a 1,134 amino acid protein that belongs to the FNDC3 family of proteins. FNDC3A contains an N-terminal proline-rich region, nine fibronectin type-III domains (none of which contain an RGD sequence) and a hydrophobic C-terminal transmembranous helix. Expressed in a wide variety of tissues, FNDC3A localizes to Golgi vesicles and to the developing acrosome of spermatids. FNDC3A is believed to function in glycosaminoglycan and collagen synthesis. In mice, a mutation in the gene encoding FNDC3A causes male sterility due to defective adhesion between Sertoli cells and spermatids in the seminiferous epithelium. This suggests that FNDC3A plays an important role in spermatogenesis, possibly mediating or maintaining the adhesion between Sertoli cells and spermatids. |
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FNDC3A Antibody Blocking Peptide(bs-13191P)-500ug
￥880
