- ￥880
- Bioss
- bs-0642P
- 2025年10月16日
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500ug
| 产品编号 | bs-0642P |
| 英文名称 | MAdCAM-1 Antibody Blocking Peptide |
| 中文名称 | 粘膜血管定居因子封闭多肽 |
| 英文别名 | Mucosal addressin cellular adhesion molecule-1; Addressin mucosal; hMAdCAM 1; MACAM1; Mucosal addressin cell adhesion molecule 1; Mucosal vascular addressin cell adhesion molecule 1; MADCA_RAT. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Angiogenesis > Adhesion / ECM > Integrins Immunology > Innate Immunity > Macrophage / Inflamm. Neuroscience > Cell Adhesion Proteins > Receptors > Integrins > Beta Integrins Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Beta |
| 亚基 | Contains 2 Ig-like (immunoglobulin-like) domains. |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. |
| 翻译后修饰 | The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation (By similarity). |
| 相似性 | Contains 2 Ig-like (immunoglobulin-like) domains. |
| 功能 | Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin Alpha 4/Beta 7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis. |
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MAdCAM-1 Antibody Blocking Peptide(bs-0642P)-500ug
￥880
