- ￥880
- Bioss
- bs-16107P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-16107P |
| 英文名称 | PRR5LAntibody Blocking Peptide |
| 中文名称 | Protor2蛋白封闭多肽 |
| 英文别名 | FLJ14213 protein; Hypothetical protein FLJ14213; Hypothetical protein LOC79899; Proline-rich protein 5-like; Protein observed with Rictor-2; Protor 2; Protor-2; PROTOR2; PRR5L; PRR5L_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL. |
| 翻译后修饰 | Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid. |
| 相似性 | Belongs to the PROTOR family. |
| 功能 | May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | mTOR is a large protein kinase that is important in cell growth and functions as the mammalian target of Rapamycin, an immunosuppressant that blocks vessel restenosis and also has potential anticancer applications. Rapamycin-insensitive companion of mTOR, also designated Rictor, forms a complex (designated mTORC2) with mTOR that directly phosphorylates Akt/PKB on Ser473 and plays a key role in growth signaling pathways. Protor-2, also known as PROTOR2 or FLJ14213, is a 368 amino acid protein that is thought to interact with the mTORC2 complex and, via this interaction, may regulate organization of the Actin cytoskeleton. Three isoforms of Protor-2 are expressed due to alternative splicing events. |
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PRR5LAntibody Blocking Peptide(bs-16107P)-500ug
￥880
