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- bs-17138P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-17138P |
| 英文名称 | SP140 Antibody Blocking Peptide |
| 中文名称 | 核自身抗原SP140封闭多肽 |
| 英文别名 | LY10_HUMAN; Lymphoid restricted homolog of Sp100; Lymphoid specific SP100 homolog; Lymphoid-restricted homolog of Sp100; LYSP100 A; LYSp100; LYSP100 B; LYSp100 protein; LYSP100-A; LYSP100-B; LYSP100A; LYSP100B; MGC126440; Nuclear antigen Sp140; Nuclear autoantigen Sp-140; Nuclear autoantigen Sp140; Nuclear body protein SP140; SP140; SP140 nuclear body protein; SP140 PEN; Speckled 140 kDa. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Immunology > Immune System Diseases > Antiviral Signaling |
| 亚基 | Interacts with PIN1. |
| 亚细胞定位 | Nucleus. Cytoplasm. Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus. |
| 组织特异性 | High levels in spleen and peripheral blood leukocytes, much lower levels in thymus, prostate, ovary, small intestine, and colon. Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. |
| 相似性 | Contains 1 bromo domain. Contains 1 HSR domain. Contains 1 PHD-type zinc finger. Contains 1 SAND domain. |
| 功能 | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SP140 is an 867 amino acid cytoplasmic and nuclear protein that is highly expressed in spleen and peripheral blood leukocytes. SP140 is a component of the nuclear body that may be involved in trafficking between the nucleus and the cytoplasm. SP140 is induced by interferons and contains a bromo domain, a HSR domain, a PHD-type zinc finger and a SAND domain. It is thought that SP140 may participate in the pathogenesis of acute promyelocytic leukemia and viral infection. SP140 is expressed as three isoforms produced by alternative splicing and are designated isoform LYSp100-A, isoform LYSp100-B and isoform SP140. |
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SP140 Antibody Blocking Peptide(bs-17138P)-500ug
￥880
