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- bs-3450P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-3450P |
| 英文名称 | Phospho-TNK1 (Tyr277) Antibody Blocking Peptide |
| 中文名称 | 磷酸化非受体型酪氨酸蛋白激酶Tnk1封闭多肽 |
| 英文别名 | CD38 negative kinase 1; EC 2.7.10.2 antibody Kinase of embryonic stem cells; Kos 1; Kos1; MGC46193; Non receptor tyrosine protein kinase TNK 1; Non receptor tyrosine protein kinase TNK1; Tnk 1; Tyrosine kinase non receptor 1. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. |
| 亚细胞定位 | Cytoplasm. Membrane; Peripheral membrane protein. |
| 组织特异性 | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. |
| 翻译后修饰 | Autophosphorylated on tyrosine residues. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain. Contains 1 SH3 domain. |
| 功能 | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Tnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity. |
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Phospho-TNK1 (Tyr277) Antibody Blocking Peptide(bs-3450P)-500ug
￥1080
