DNAH1 Antibody Blocking Peptide(bs-14359P)-500ug

DNAH1 Antibody Blocking Peptid

e(bs-14359P)-500ug
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  • bs-14359P
  • 2025年10月16日
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      500ug

    产品编号bs-14359P
    英文名称DNAH1 Antibody Blocking Peptide
    中文名称轴丝动力蛋白1封闭多肽
    英文别名axonemal; Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; DNAH1; DNAHC1; DYH1_HUMAN; Dynein heavy chain 1; hDHC7; Heat shock regulated protein 1; Ciliary dynein heavy chain 1; HL 11; HL11; HSRF-1; XLHSRF-1.
    纯化方法HPLC
    亚细胞定位Cytoplasm > cytoskeleton > cilium axoneme.
    组织特异性Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain.
    相似性Belongs to the dynein heavy chain family.
    功能Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH1 (dynein heavy chain 1, axonemal), also known as heat shock regulated protein 1 or ciliary dynein heavy chain 1, is a 4,330 amino acid protein consisting of at least two heavy chains and several intermediate and light chains. Mutations in the gene encoding DNAH1 may be a cause of primary ciliary dyskinesia, also known as Kartagener Syndrome, which is characterized by chronic recurrent respiratory infections due to defective cilia action in the respiratory tract. There are three isoforms of DNAH1 that exist as a result of alternative splicing events.

     

     

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