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500ug
| 产品编号 | bs-3365P |
| 英文名称 | Phospho-RSK3 (Thr353/356) Antibody Blocking Peptide |
| 中文名称 | 磷酸化核糖体蛋白S6激酶家族RSK3封闭多肽 |
| 英文别名 | RSK3 (Phospho T353 + T356); Phospho-RSK3 (Thr353 + Thr356); 90 kDa ribosomal protein S6 kinase 2; HU 2; KS6A2_HUMAN; MAP kinase activated protein kinase 1c; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; p90-RSK 2; p90RSK 2; p90RSK2; pp90RSK 3; pp90RSK3; Ribosomal protein S6 kinase alpha-2; Ribosomal S6 kinase 3; RPS6KA2; RSK 3; RSK-3; S6K alpha 2; S6K alpha; S6K-alpha-2. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > Translation > Ribosome Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚基 | Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 inquiescent cells. Transiently dissociates following mitogenicstimulation. |
| 亚细胞定位 | Nucleus. Cytoplasm. |
| 组织特异性 | Widely expressed with higher expression inlung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. |
| 翻译后修饰 | Activated by phosphorylation at Ser-218 by PDPK1.Autophosphorylated on Ser-377, as part of the activation process.May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 andMAPK3/ERK1.
N-terminal myristoylation results in an activated kinase inthe absence of added growth factors. |
| 相似性 | Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. S6 kinase subfamily.
Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains. |
| 功能 | Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. |
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文献和实验Absorption Control in Immunohistochemistry Using Phospho-Peptides Immobilized on Magnetic Beads
neutralization of phospho-specific antibodies with phospho-peptides immobilized on magnetic beads. This technique allows for sequestration of antibody–peptide complex from the incubation solution, minimizing the risk of formation of unblocked antibodies capable
or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Phospho-Specific Antibodies as a Tool to Study In Vivo Regulation of BRCA1 After DNA Damage
a significant level of antibodies specific to the nonphosphorylated peptide is present in the antisera, an enhancement step is used to obtain a useful phospho-specific antibody. Although these enhanced antisera are suitable for many applications
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