- ￥880
- Bioss
- bs-17111P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17111P |
| 英文名称 | LAX1 Antibody Blocking Peptide |
| 中文名称 | 膜相关接头蛋白LAX封闭多肽 |
| 英文别名 | FLJ20340; LAT like membrane associated protein; LAX; LAX1_HUMAN; Linker for activation of X cells; Lymphocyte transmembrane adaptor 1; Membrane associated adapter protein LAX; OTTHUMP00000034094. |
| 纯化方法 | HPLC |
| 亚基 | When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2. |
| 亚细胞定位 | Cell Membrane; Single-pass type III membrane protein. |
| 组织特异性 | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. |
| 翻译后修饰 | Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. |
| 功能 | LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | LAX1 is a 398 amino acid single-pass type III membrane protein that negatively regulates lymphocyte signaling. LAX1 is expressed in lymphoid tissues including thymus, spleen and peripheral blood leukocytes, along with several B-cell, T-cell, natural killer and monocyte cell lines. When stimulated by B or T cells, LAX1 becomes dramatically upregulated and also interacts with GRB2, Gads and PI 3-kinase p85 upon phosphorylation. LAX1 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 1. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. |
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LAX1 Antibody Blocking Peptide(bs-17111P)-500ug
￥880
