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- Bioss
- bs-11863P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11863P |
| 英文名称 | SHTN1 Antibody Blocking Peptide |
| 中文名称 | 阅读障碍相关蛋白Shootin封闭多肽 |
| 英文别名 | DKFZp686A0439; hypothetical protein FLJ11122; Kiaa1598; MGC40476; Putative uncharacterized protein KIAA1598; Shootin 1; Shootin-1; Shootin; SHOT1_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with RUFY3 |
| 亚细胞定位 | Cell projection. |
| 相似性 | Belongs to the shootin family. |
| 功能 | Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Shootin1 is a 631 amino acid protein that belongs to the shootin family. The shootin1 protein contains three coiled-coil domains, a proline-rich region and interacts with RUFY3. Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization. The shootin1 protein acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. By accumulating asymmetrically in a single neurite before polarization, shootin1 leads to axon induction for polarization, additionally the absence of shootin1 from the nascent axon's siblings by competition prevents the formation of surplus axons. Existing as seven alternatively spliced isoforms, the shootin1 gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 10q25.3. |
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SHTN1 Antibody Blocking Peptide(bs-11863P)-500ug
￥880
