- ￥880
- Bioss
- bs-2709P
- 2025年10月16日
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500ug
| 产品编号 | bs-2709P |
| 英文名称 | SLAMF1 Antibody Blocking Peptide |
| 中文名称 | 信号淋巴细胞活化分子CD150封闭多肽 |
| 英文别名 | CD150 antigen; Cdw150; SLAM / CD150; Estm51; Ipo 3; Ipo3; MGC151472; MGC151476; Signaling lymphocytic activation molecule; Signaling lymphocytic activation molecule family member 1; Signaling lymphocytic activation molecule precursor; Slaf1; SLAM family, member 1; Slamf; Slamf1; SLAMF1 protein. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Angiogenesis > Endothelial Cell Markers Immunology > Cell Type Markers > CD > Non-lineage Microbiology > Interspecies Interaction > Host Virus Interaction Stem Cells > Hematopoietic Progenitors > Hematopoietic Stem Cells > HSC markers Stem Cells > Hematopoietic Progenitors > Surface Molecules |
| 亚基 | nteracts (via cytoplasmic domain) with SH2D1A, and withPTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus Hprotein and acts as a receptor for this virus. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. |
| 组织特异性 | Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation. |
| 翻译后修饰 | Phosphorylated by FYN. |
| 相似性 | Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SLAM, a novel glycoprotein of 37kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and the expression levels of membrane bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. |
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SLAMF1 Antibody Blocking Peptide(bs-2709P)-500ug
￥880
