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- 2025年10月16日
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| 产品编号 | bs-46539P |
| 英文名称 | Recombinant human Alpha-synuclein |
| 中文名称 | 重组人核突触蛋白 |
| 英文别名 | SYUA_HUMAN; Alpha-synuclein; Alpha synuclein; SNCA; NACP; PARK1; |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 15.4 |
| 实际分子量 | 20kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | Supplied as solution form in PBS (pH7.4) or lyophilized from PBS (pH7.4). |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Tangles & Tau Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease > Synuclein |
| 亚基 | Soluble monomer which can form filamentous aggregates. Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Subcellular Location : Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons. |
| 亚细胞定位 | Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons. |
| 组织特异性 | Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
| 翻译后修饰 | Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers. Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity). Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. |
| 相似性 | Belongs to the synuclein family. |
| 功能 | May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]. |
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