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- Bioss
- bs-41179P
- 2025年10月16日
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- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-41179P |
| 英文名称 | Recombinant human NGAL protein, His |
| 中文名称 | 重组人NGAL蛋白 |
| 英文别名 | Lipocalin 2; Oncogene 24p3; 25 KDa Alpha-2-Microglobulin-Related Subunit Of MMP-9; Neutrophil Gelatinase-Associated Lipocalin; Siderocalin LCN2; P25; Migration-Stimulating Factor Inhibitor; Lipocalin 2 (Oncogene 24p3); Siderocalin; Lipocalin-2; 24p3; MSFI; HNL; Recombinant human NGAL protein, His |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 25 |
| 实际分子量 | 32 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 20mM Tris-HCl (pH8.0) with 300mM NaCl, 500mM imidazole and 5% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Binding proteins Immunology > Adaptive Immunity > T Cells > Non-CD Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Fatty acids Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Lipid metabolism |
| 亚基 | Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9. |
| 亚细胞定位 | Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized. |
| 组织特异性 | Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. |
| 相似性 | Belongs to the calycin superfamily. Lipocalin family. |
| 功能 | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Lipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances. |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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Recombinant human NGAL protein, His(bs-41179P)-100ug/500ug/20ug
￥580 - 5680
