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- Bioss
- bs-11848P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11848P |
| 英文名称 | GPR56 Antibody Blocking Peptide |
| 中文名称 | 蛋白偶联受体56封闭多肽 |
| 英文别名 | BFPP; DKFZp781L1398; EGF TM7 like; G protein coupled receptor 56; GPR 56 ; Polymicrogyria bilateral frontoparietal; TM7LN4; TM7XN1; TM7XN1 protein; GPR56_HUMAN. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cell membrane. Multi-pass membrane protein. |
| 组织特异性 | Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. |
| 翻译后修饰 | The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. |
| 相似性 | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. |
| 功能 | GPR56 contains 7 transmembrane domains as well as a mucin-like domain and cysteine box in the N-terminal region. Its expression is widely distributed and the highest levels can be found in brain, thyroid gland and heart. It is also expressed in a great number of tumor cells. Results show that mutations in GPR56 cause a human brain cortical malformation called bilateral frontoparietal polymicrogyria (BFPP); data suggest that GPR56 signaling plays an essential role in regional development of human cerebral cortex. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions. G-protein coupled receptor 56 (GPR56), also designated TM7XN1 protein, contains one GPS domain. GPR56 plays an important role in cell-cell interactions and is widely expressed, with highest levels detected in brain, heart and thyroid gland. Defects in the gene encoding for GPR56 can cause bilateral frontoparietal polymicrogyria (BFPP) which is characterized by disorganized cortical lamination. |
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GPR56 Antibody Blocking Peptide(bs-11848P)-500ug
￥880
