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- Bioss
- bs-11843P
- 2025年10月16日
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500ug
| 产品编号 | bs-11843P |
| 英文名称 | GDF6 Antibody Blocking Peptide |
| 中文名称 | 生长分化因子6封闭多肽 |
| 英文别名 | bmp 13; bmp13; bmp-13; Cartilage Derived Morphogenetic Protein 2; cdmp 2; CDMP2; gdf 6; GDF16 ; Growth differentiation factor 6; Growth/differentiation factor 6; GDF6_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurogenesis Neuroscience > Sensory System > Visual system Signal Transduction > Growth Factors/Hormones > TGF |
| 亚基 | Homodimer; disulfide-linked |
| 亚细胞定位 | Secreted |
| 相似性 | Belongs to the TGF-beta family. |
| 功能 | GDF6 (Growth/differentiation factor 6) is expressed in hypertrophic chondrocytes during embryonic development of long bones and is required for normal formation of bones and joints in the limbs, skull, and axial skeleton. It plays a key role in establishing boundaries between skeletal elements during development. The functional form of GDF6 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains obtained by proteolytic processing of a biologically inactive precursor protein. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1). |
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GDF6 Antibody Blocking Peptide(bs-11843P)-500ug
￥880
