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- Bioss
- bs-13137P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13137P |
| 英文名称 | FAN1 Antibody Blocking Peptide |
| 中文名称 | 范可尼综合征相关蛋白FAN1封闭多肽 |
| 英文别名 | 6030441H18Rik; Coiled coil domain containing protein MTMR15; DKFZp451H236; DKFZp686K16147; FAN1; FAN1_HUMAN; FANCD2/FANCI associated nuclease 1; FANCD2/FANCI-associated nuclease 1; Fanconi associated nuclease 1; Fanconi-associated nuclease 1; KIAA1018; MTMR 15; MTMR15; Myotubularin related protein 15; Myotubularin-related protein 15. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Fanconi's Anemia |
| 亚基 | Interacts with FANCD2 (when monoubiquitinated). Interacts with FANCI, MLH1, MLH3 and PMS2. |
| 亚细胞定位 | Nucleus. Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2. |
| 相似性 | Belongs to the FAN1 family. Contains 1 UBZ-type zinc finger. Contains 1 VRR-NUC domain. |
| 功能 | Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template. |
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FAN1 Antibody Blocking Peptide(bs-13137P)-500ug
￥880
