- ￥880
- Bioss
- bs-2702P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2702P |
| 英文名称 | Sema7A Antibody Blocking Peptide |
| 中文名称 | 轴突生长因子CD108封闭多肽 |
| 英文别名 | semaphorin 7A; CD 108; CD108; CD108 antigen; CDw108; H Sema K1; H Sema L; JMH; JMH blood group antigen; John Milton Hagen blood group H Sema K1; John Milton Hargen human blood group Ag; MGC126692; MGC126696; Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A; Sema L; Sema7a; SEMAK1; SEMAL; Semaphorin 7A GPI membrane anchor; Semaphorin K1; Semaphorin L; Semaphorin7a; SEM7A_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Neuroscience > Neurology process > Neurogenesis |
| 亚基 | Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1. |
| 亚细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes. |
| 组织特异性 | Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. |
| 相似性 | Belongs to the semaphorin family. |
| 功能 | Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Semaphorin 7a is required for central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Semaphorin 7a is also involved in modulating immune function. Semaphorin 7a expression is highest in the brain and increases in late embryonic and postnatal stages. The Semaphorins constitute a large family of secreted and membrane-tethered cell signaling molecules. They have functions in neural development, immunology, cardiac growth, vascular development, lung morphogenesis and axial bone patterning. Semaphorins are defined by the presence of a conserved Sema domain at the N-terminus. These proteins can be classified into eight classes depending on their structure and species origin. Classes 3 through 7 are found in vertebrates; class 3 are secreted, class 7 are GPI-anchored, and class 4 through 6 are transmembrane proteins. |
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Sema7A Antibody Blocking Peptide(bs-2702P)-500ug
￥880
