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- Bioss
- bs-2694P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2694P |
| 英文名称 | TLR11 Antibody Blocking Peptide |
| 中文名称 | Toll样受体11封闭多肽 |
| 英文别名 | Toll like receptor 11; Gm287; MGC129352; MGC129353; RGD1564460; TLR11_MOUSE. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Receptors Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > TLR Signaling Microbiology > Protein > Human Protein > Defensin |
| 亚基 | Binds MYD88 via their respective TIR domains. Interacts with HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 相似性 | Belongs to the Toll-like receptor family. Contains 10 LRR (leucine-rich) repeats. Contains 1 TIR domain. |
| 功能 | Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Toll like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system. |
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TLR11 Antibody Blocking Peptide(bs-2694P)-500ug
￥880
