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- bs-3218P
- 2025年10月16日
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500ug
| 产品编号 | bs-3218P |
| 英文名称 | Phospho-ERBB3 (Tyr1197) Antibody Blocking Peptide |
| 中文名称 | 磷酸化HER3封闭多肽 |
| 英文别名 | Her3/ErbB3(phospho-Tyr1197); p-HRE3 (Tyr1197); ErbB 3 (phospho Y1197); ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER3; LCCS2; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c ErbB 3; proto-oncogene-like protein c ErbB3; receptor tyrosine protein kinase ERB3; Receptor tyrosine protein kinase erbB 3; Receptor tyrosine protein kinase erbB3; Tyrosine kinase type cell surface receptor HER3; ERBB3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Growth factors > EGF Cancer > Oncoproteins/suppressors > Oncoproteins > Growth factor receptors Cancer > Tumor biomarkers > Oncoproteins Signal Transduction > Growth Factors/Hormones > EGF Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases Signal Transduction > Signaling Pathway > G Protein Signaling > Heterotrimeric G Proteins > G Proteins |
| 亚基 | Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4, GRB7 and MUC1. |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I. membrane protein. Isoform 2: Secreted. |
| 组织特异性 | Epithelial tissues and brain. |
| 翻译后修饰 | Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. Subject to autophosphorylation. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain. |
| 功能 | Binds and is activated by neuregulins and NTAK. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. |
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Phospho-ERBB3 (Tyr1197) Antibody Blocking Peptide(bs-3218P)-500ug
￥1080
