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- Bioss
- bs-13084P
- 2025年10月16日
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500ug
| 产品编号 | bs-13084P |
| 英文名称 | phospho-NGEF (Tyr179) Antibody Blocking Peptide |
| 中文名称 | 磷酸化神经细胞鸟苷酸置换因子Ephexin1封闭多肽 |
| 英文别名 | Ephexin-1 (phospho Y179); p-Ephexin-1 (phospho Y179); ARHGEF27; Eph-interacting exchange protein; EPHEXIN; Ephexin 1; Neuronal guanine nucleotide exchange factor; Ngef; NGEF_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Neuroscience > Neurology process > Neural Signal Transduction Neuroscience > Neurology process > Neurogenesis Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Regulators |
| 亚基 | Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase |
| 亚细胞定位 | Cytoplasm. Membrane. Cell projection, growth cone. Associated with membranes. Localizes to axonal growth cones. |
| 组织特异性 | Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. |
| 翻译后修饰 | Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. |
| 相似性 | Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 SH3 domain. |
| 功能 | Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species. |
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phospho-NGEF (Tyr179) Antibody Blocking Peptide(bs-13084P)-500ug
￥1080
