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- bs-3276P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-3276P |
| 英文名称 | Phospho-MEK6 (Ser202) Antibody Blocking Peptide |
| 中文名称 | 磷酸化丝裂原活化蛋白激酶MKK6封闭多肽 |
| 英文别名 | MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK6; MEK6; Mitogen Activated Protein Kinase Kinase 6; MKK 6; MKK6; PRKMK6; SAPKK3; Dual specificity mitogen activated protein kinase kinase 6; MKK 6; Dual specificity mitogen activated protein kinase kinase 6; EC 2.7.12.2; MP2K6_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > Protein phosphorylation > Serine/threonine kinases > MAPK pathway Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway |
| 亚基 | Interacts with Yersinia yopJ. |
| 亚细胞定位 | |
| 组织特异性 | Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. |
| 翻译后修饰 | Weakly autophosphorylated. Phosphorylated by TAOK2. Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| 相似性 | Belongs to the enoyl-CoA hydratase/isomerase family. |
| 功能 | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress.As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. |
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Phospho-MEK6 (Ser202) Antibody Blocking Peptide(bs-3276P)-500ug
￥1080
