- ￥880
- Bioss
- bs-11836P
- 2025年10月16日
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500ug
| 产品编号 | bs-11836P |
| 英文名称 | DACT2 Antibody Blocking Peptide |
| 中文名称 | Dapper2蛋白封闭多肽 |
| 英文别名 | bA503C24.7; C6orf116; Chromosome 6 open reading frame 116; Dact2; DACT2_HUMAN; Dapper antagonist of beta catenin homolog 2; Dapper antagonist of beta catenin homolog 2 Xenopus laevis; Dapper homolog 2 antagonist of beta catenin; Dapper homolog 2 antagonist of beta catenin xenopus; Dapper homolog 2; DAPPER2; DPR2; FLJ31232; MGC133141; MGC133142 ; RP11 503C24.7. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurogenesis Stem Cells > Signaling Pathways > Wnt > Cytoplasmic |
| 亚基 | Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity). |
| 相似性 | Belongs to the dapper family. |
| 功能 | Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Dapper2 is a 774 amino acid protein that exists as multiple alternatively spliced isoforms and is a mammalian homolog of the Xenopus laevis protein dapper. Containing a C-terminal PDZ-binding motif, Dapper2 is thought to promote the lysosomal degradation of nodal receptors, possibly functioning to negatively regulate the nodal signaling pathway. The gene encoding Dapper2 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |
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DACT2 Antibody Blocking Peptide(bs-11836P)-500ug
￥880
