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- Bioss
- bs-11831P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11831P |
| 英文名称 | Chordin Antibody Blocking Peptide |
| 中文名称 | 原肠胚双向形成相关蛋白封闭多肽 |
| 英文别名 | Chordin; Chrd; CHRD_HUMAN; MGC133038; Shortgastrulation protein; SOG. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Embryogenesis > Morphogens Developmental Biology > Lineage specification > Ectoderm Neuroscience > Neurology process > Neurogenesis Stem Cells > Lineage Markers > Ectoderm |
| 亚基 | Interacts with TWSG1 and/or BMP4 |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed at the highest level in liver. |
| 翻译后修饰 | Cleaved by tolloid proteases; cleavage participates to dorsoventral patterning during early development. |
| 相似性 | Belongs to the chordin family. Contains 4 CHRD domains. Contains 4 VWFC domains. |
| 功能 | Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The patterning of the CNS relies on the interaction of multiple signaling molecules such as Sonic Hedgehog, Wnts, and BMPs and their antagonists Chordin and Noggin. At midgastrula, expression of Noggin overlaps that of Chordin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The gene which encodeschordin maps to human chromosome 3q27. Noggin is a secreted protein that binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins, such as BMP-2,4,7. The gene which encodes noggin maps to human chromosome 17q22. |
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Chordin Antibody Blocking Peptide(bs-11831P)-500ug
￥880
