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- Bioss
- bs-11814P
- 2025年10月16日
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- 详细信息
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- 规格：
500ug
| 产品编号 | bs-11814P |
| 英文名称 | CBLN1 Antibody Blocking Peptide |
| 中文名称 | 小脑肽1封闭多肽 |
| 英文别名 | CBLN 1; Cerebellin 1; Cerebellin 1 precursor; Cerebellin1; Precerebellin; CBLN1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurogenesis Neuroscience > Neurotransmitter > Biogenic Amines > Noradrenaline |
| 亚基 | Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers. Probably forms a heteomeric complex with CBLN3. May interact with CBLN2 and CBLN4 |
| 亚细胞定位 | Secreted. Membrane. Cell junction, synapse. |
| 组织特异性 | In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin. |
| 翻译后修饰 | The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein. |
| 相似性 | Contains 1 C1q domain. |
| 功能 | CBLN1 is required for synapse integrity and synaptic plasticity. It is required for the ER export and secretion of CBLN3. CBLN1 exerts neuromodulatory functions. It directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases. |
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CBLN1 Antibody Blocking Peptide(bs-11814P)-500ug
￥880
