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- Bioss
- bs-1565P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-1565P |
| 英文名称 | APCDD1 Antibody Blocking Peptide |
| 中文名称 | 腺瘤性息肉调节蛋白封闭多肽 |
| 英文别名 | adenomatosio polyposis coli down-regulated 1; Adenomatosis polyposis coli down regulated 1; Adenomatosis polyposis coli down regulated 1 protein; APCDD 1; B7323; DRAPC1; FP7019; Protein APCDD1; APCD1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction Stem Cells > Signaling Pathways > Wnt > Surface Molecules |
| 亚基 | Homodimer. Interacts with LRP5 and WNT3A. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 组织特异性 | Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level). |
| 翻译后修饰 | N-Glycosylated. |
| 相似性 | Belongs to the APCDD1 family. |
| 功能 | Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | APCDD1 is a novel protein that has been shown to be a target of Wnt/beta catenin signaling pathway in cancer cell lines. APCDD1 is overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1 mutated Wilms tumors.[FUNCTION] Probably plays a role in colorectal tumorigenesis. May be a developmental target gene of the Wnt/Beta-catenin pathway.[SUBCELLULAR LOCATION] Membrane; Single-pass type I membrane protein (Potential). [TISSUE SPECIFICITY] Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. [INDUCTION] Transcriptionally regulated by the CTNNB1/TF7L2complex. |
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APCDD1 Antibody Blocking Peptide(bs-1565P)-500ug
￥880
