- ￥880
- Bioss
- bs-1561P
- 2025年10月16日
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500ug
| 产品编号 | bs-1561P |
| 英文名称 | DTNBP1 Antibody Blocking Peptide |
| 中文名称 | 精神分裂症易感基因封闭多肽 |
| 英文别名 | Dysbindin-1; 5430437B18Rik; AW048963; dysbindin; sdy; DTNBP1; Dystrobrevin binding protein 1; Hermansky Pudlak syndrome 7 protein; HPS7; DTBP1_HUMAN; Dystrobrevin-binding protein-1; Hermansky-Pudlak syndrome 7 protein; HPS7 protein. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease |
| 亚细胞定位 | Cytoplasm. Cytoplasmic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Endosome membrane. Melanosome membrane. Nucleus. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Endoplasmic reticulum. Detected in neuron cell bodies, axons and dendrites. Detected at synapses, at post-synaptic density, at pre-synaptic vesicle membranes and microtubules. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes. Occasionally detected at the membrane of pigmented melanosomes in cultured melanoma cells. |
| 组织特异性 | Detected in brain, in neurons and in neuropil. Detected in dentate gyrus and in pyramidal cells of hippocampus CA2 and CA3 (at protein level). |
| 翻译后修饰 | Ubiquitinated by TRIM32. Ubiquitination leads to DTNBP1 degradation. Phosphorylated by PRKDC. |
| 相似性 | Belongs to the dysbindin family. |
| 功能 | The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Dysbindin may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC1), and binds to alpha and beta dystrobrevins, which are components of the dystrophin associated protein complex (DPC). Mutations in Dysbindin gene are associated with Hermansky-Pudlak syndrome type 7. Dysbindin gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. |
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DTNBP1 Antibody Blocking Peptide(bs-1561P)-500ug
￥880
