- ￥880
- Bioss
- bs-1560P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-1560P |
| 英文名称 | RELN Antibody Blocking Peptide |
| 中文名称 | 络丝蛋白封闭多肽 |
| 英文别名 | Reelin; Reeler; RELN; RL; LIS2; PRO1598; RELN_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > ECM Proteins Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Neuroscience > Neurology process > Neurogenesis |
| 亚细胞定位 | Secreted |
| 组织特异性 | High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level). |
| 翻译后修饰 | N-glycosylated; more than 90% of the glycans are sialylated. |
| 相似性 | Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains. |
| 功能 | This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in “reeler” mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signaling pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF. |
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RELN Antibody Blocking Peptide(bs-1560P)-500ug
￥880
