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- Bioss
- bs-7389P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7389P |
| 英文名称 | TNKS2 Antibody Blocking Peptide |
| 中文名称 | 端粒调控因子2封闭多肽 |
| 英文别名 | ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; PARP 5b; PARP 5c; PARP-5b; PARP-5c; PARP5B; PARP5C; pART6; Poly [ADP ribose] polymerase 5B; Poly [ADP-ribose] polymerase 5B; TANK2; Tankyrase 2; Tankyrase II; Tankyrase like protein; Tankyrase related protein; Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2; Tankyrase-2; Tankyrase-like protein; Tankyrase-related protein; TNKL; TNKS 2; TNKS-2; TNKS2; TNKS2_HUMAN; TRF1 Interacting Ankyrin Related ADP ribose polymerase 2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromosome Structure > Telomeres Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚细胞定位 | Cytoplasm. Golgi apparatus membrane. Nucleus. Chromosome > telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1. |
| 组织特异性 | Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain. |
| 翻译后修饰 | Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer. |
| 相似性 | Contains 15 ANK repeats. Contains 1 PARP catalytic domain. Contains 1 SAM (sterile alpha motif) domain. |
| 功能 | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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TNKS2 Antibody Blocking Peptide(bs-7389P)-500ug
￥880
