- ￥880
- Bioss
- bs-0280P
- 2025年10月16日
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500ug
| 产品编号 | bs-0280P |
| 英文名称 | PIGF Antibody Blocking Peptide |
| 中文名称 | 胎盘生长因子封闭多肽 |
| 英文别名 | Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 亚基 | Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. |
| 亚细胞定位 | Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. |
| 组织特异性 | While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Belongs to the PDGF/VEGF growth factor family. |
| 功能 | Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The placental-derived growth factor (PIGF) is a dimeric glycoprotein showing a high degree of sequence similarity to the vascular endothelial growth factor. Alternative splicing of the PIGF primary transcript gives rise to two forms, named PIGF-1 and PIGF-2, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. The presence of the PIGF mRNA in thyroid, placenta, lung, and goiter has indicated the tissues where this factor functions. However, the role of PIGF in vascular development has not yet been clearly established. |
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PIGF Antibody Blocking Peptide(bs-0280P)-500ug
￥880
